Numerous articles compared various therapies for carpal tunnel against other therapies. Not only were the treatments and their comparisons very heterogeneous, but no long-term follow also up was described either – as such, this recommendation has been downgraded. The majority of the studies did not demonstrate any significant difference between the treatment arms. When comparing corticosteroid injection versus shockwave therapy, the results were equivocal with one study out of four favoring ESWT, another favoring CSI, and two showing no significant difference between the treatment groups. When comparing ESWT with various treatments, three studies showed a slight benefit in ESWT.
Benefits/Harms of Implementation
The above non operative treatments do not show a consistent significant difference from other treatments and add to the time and monetary expense for patients suffering from CTS.
Outcome Importance
As there is limited data with mixed quality of evidence, any particular non-operative treatment cannot be recommended over another non-operative treatment.
Cost Effectiveness/Resource Utilization
None of the non-operative treatments have shown long-term success in the treatment of CTS and therefore, are not considered cost-effective options.
Acceptability
Due to lack of supporting evidence, this guideline is anticipated to be accepted by surgeons, patients, and therapists.
Feasibility
Readily available and feasible to not use these modalities.
Future Research
No long-term follow up studies are available to confirm the lack of effectiveness of these therapies, however, are likely not necessary, given the lack of short-term benefits.
- Asheghan, M., Aghda, A. K., Sobhani, V., Hashemi, S. E., Hollisaz, M. T.. (2020). A randomized comparative trial of corticosteroid phonophoresis, local corticosteroid injection, and low-level laser in the treatment of carpal tunnel syndrome. Laser Therapy, 29(1), 11-17.
- Atthakomol, P., Manosroi, W., Phanphaisarn, A., Phrompaet, S., Iammatavee, S., Tongprasert, S.. (2018). Comparison of single-dose radial extracorporeal shock wave and local corticosteroid injection for treatment of carpal tunnel syndrome including mid-term efficacy: a prospective randomized controlled trial. BMC Musculoskeletal Disorders, 19(1), 32.
- Celenlioglu, A. E., Unal-Artik, H. A., Guler, G.. (2022). Comparison of ultrasound-guided pulsed radiofrequency versus steroid injection in the treatment of carpal tunnel syndrome. Irish Journal of Medical Science, 17(0), 17.
- Chang, C. Y., Chen, L. C., Chou, Y. C., Li, T. Y., Ho, T. Y., Wu, Y. T.. (2020). The Effectiveness of Platelet-Rich Plasma and Radial Extracorporeal Shock Wave Compared with Platelet-Rich Plasma in the Treatment of Moderate Carpal Tunnel Syndrome. Pain Medicine, 21(8), 1668-1675.
- Dernek, B., Aydin, T., Koseoglu, P. K., Kesiktas, F. N., Yesilyurt, T., Diracoglu, D., Aksoy, C.. (2017). Comparison of the efficacy of lidocaine and betamethasone dipropionate in carpal tunnel syndrome injection. Journal of Back & Musculoskeletal Rehabilitation, 30(3), 435-440.
- Dilokhuttakarn, T., Lertnantapanya, S., Vechmamontien, S., Suwanchatchai, C.. (2018). The efficacy of dexamethasone sodium phosphate compared to triamcinolone acetonide in the treatment of carpal tunnel syndrome: A randomized double-blind controlled trial. Journal of the Medical Association of Thailand, 101(12), 1634-1639. https://www.embase.com/search/results?subaction=viewrecord&id=L626034668&from=export
- Elawamy, A., Hassanien, M., Hamed, A., Roushdy, A. S. I., Abass, N. A., Mohammed, G., Hasan, Mrar, Kamel, E. Z.. (2020). Efficacy of Hyalase Hydrodissection in the Treatment of Carpal Tunnel Syndrome: A Randomized, Double-Blind, Controlled, Clinical Trial. Pain Physician, 23(2), E175-E183.
- Elhak, Rkaeg, Battesha, H. H. M., Samir, S. M.. (2021). Muscle energy technique versus active release technique on motor functions in patients with carpal tunnel syndrome. International journal of therapy and rehabilitation, 28(7), 1-11. https://www.cochranelibrary.com/central/doi/10.1002/central/CN-02367821/full
- Geler Kulcu, D., Bursali, C., Aktas, I., Bozkurt Alp, S., Unlu Ozkan, F., Akpinar, P.. (2016). Kinesiotaping as an alternative treatment method for carpal tunnel syndrome. Turkish Journal of Medical Sciences, 46(4), 1042-9.
- Günay, B., Alp, A.. (2015). The effectiveness of carpal bone mobilization accompanied by night splinting in idiopathic carpal tunnel syndrome. Turkiye Fiziksel Tip ve Rehabilitasyon Dergisi, 61(1), 45-50. http://dx.doi.org/10.5152/tftrd.2015.70446
- Haghighat, S., Khosravi, M., Rezaei, M.. (2021). The Effect of Shock Wave and Phonophoresis in the Improvement of the Clinical Symptoms and Function of Patients with Mild to Moderate Carpal Tunnel Syndrome: A Clinical Trial. Medical Journal of the Islamic Republic of Iran, 35(0), 179.
- Hall, B., Lee, H. C., Fitzgerald, H., Byrne, B., Barton, A., Lee, A. H.. (2013). Investigating the effectiveness of full-time wrist splinting and education in the treatment of carpal tunnel syndrome: a randomized controlled trial. American Journal of Occupational Therapy, 67(4), 448-59.
- Hamoda, R. E., Osman, D. A., Hamada, H. A., Radwan, R., Yousef, A. M., Abdel Samea, G. A., Gharib, H. O.. (2019). Effect of myofascial release on electrophysiological and clinical measures of pregnant women with carpal tunnel syndrome. Physiotherapy Quarterly, 27(1), 18-24. http://dx.doi.org/10.5114/pq.2019.83057
- Hamzeh, H., Madi, M., Alghwiri, A. A., Hawamdeh, Z.. (2021). The long-term effect of neurodynamics vs exercise therapy on pain and function in people with carpal tunnel syndrome: A randomized parallel-group clinical trial. Journal of Hand Therapy, 34(4), 521-530.
- Hesami, O., Haghighatzadeh, M., Lima, B. S., Emadi, N., Salehi, S.. (2018). The effectiveness of gabapentin and exercises in the treatment of carpal tunnel syndrome: a randomized clinical trial. Journal of exercise rehabilitation, 14(6), 1067-1073.
- Kamel, S. R., Sadek, H. A., Hamed, A., Sayed, O. A., Mahmud, M. H., Mohamed, F. A., El Sagher, G. M., Aly, L. H.. (2019). Ultrasound-guided insulin injection for carpal tunnel syndrome in type 2 diabetes mellitus patients. Clinical Rheumatology, 38(10), 2933-2940.
- Kocak Ulucakoy, R., Yurdakul, F. G., Bodur, H.. (2020). Extracorporeal shock wave therapy as a conservative treatment option for carpal tunnel syndrome: A double-blind, prospective, randomized, placebo-controlled study. Turkish Journal of Physical Medicine and Rehabilitation, 66(4), 388-397.
- Mathew, M. M., Gaur, R., Gonnade, N., Asthana, S. S., Ghuleliya, R.. (2022). Efficacy of Ultrasound-Guided Particulate Versus Nonparticulate Steroid Injection in Carpal Tunnel Syndrome: An Open-Label Randomized Control Trial. Cureus, 14(1), e21591.
- Notarnicola, A., Maccagnano, G., Tafuri, S., Fiore, A., Pesce, V., Moretti, B.. (2015). Comparison of shock wave therapy and nutraceutical composed of Echinacea angustifolia, alpha lipoic acid, conjugated linoleic acid and quercetin (perinerv) in patients with carpal tunnel syndrome. , 28(2), 256-62.
- OsmanoGLu, K., YildizgÖRen, M. T., GÜLer, H., TurhanoGLu, A. D.. (2022). Comparison of the Therapeutic Efficacy of Extracorporeal Shock Wave Therapy Versus Corticosteroid Iontophoresis in Carpal Tunnel Syndrome: a Prospective Randomized Study. Journal of physical medicine & rehabilitation sciences, 25(1), 63-72. https://www.cochranelibrary.com/central/doi/10.1002/central/CN-02382906/full
- Ozturk Durmaz, H., Tuncay, F., Durmaz, H., Erdem, H. R.. (2022). Comparison of Radial Extracorporeal Shock Wave Therapy and Local Corticosteroid Injection Effectiveness in Patients With Carpal Tunnel Syndrome: A Randomized Controlled Study. American Journal of Physical Medicine & Rehabilitation, 101(7), 685-692.
- Pratelli, E., Pintucci, M., Cultrera, P., Baldini, E., Stecco, A., Petrocelli, A., Pasquetti, P.. (2015). Conservative treatment of carpal tunnel syndrome: comparison between laser therapy and Fascial Manipulation( R). Journal of Bodywork & Movement Therapies, 19(1), 113-8.
- Raeissadat, S. A., Karimzadeh, A., Hashemi, M., Bagherzadeh, L.. (2018). Safety and efficacy of platelet-rich plasma in treatment of carpal tunnel syndrome; a randomized controlled trial. BMC Musculoskeletal Disorders, 19(1), 49.
- Saglam, G., Cetinkaya Alisar, D., Ozen, S.. (2022). Physical therapy versus radial extracorporeal shock wave therapy in the treatment of carpal tunnel syndrome: A randomized-controlled study. Turkish Journal of Physical Medicine and Rehabilitation, 68(1), 126-135.
- Seok, H., Kim, S. H.. (2013). The effectiveness of extracorporeal shock wave therapy vs. local steroid injection for management of carpal tunnel syndrome: a randomized controlled trial. American Journal of Physical Medicine & Rehabilitation, 92(4), 327-34.
- Sheereen, F. J., Sarkar, B., Sahay, P., Shaphe, M. A., Alghadir, A. H., Iqbal, A., Ali, T., Ahmad, F.. (2022). Comparison of Two Manual Therapy Programs, including Tendon Gliding Exercises as a Common Adjunct, While Managing the Participants with Chronic Carpal Tunnel Syndrome. Pain Research & Management, 2022(0), 1975803.
- Shen, Y. P., Li, T. Y., Chou, Y. C., Chen, L. C., Wu, Y. T.. (2021). Outcome predictors of platelet-rich plasma injection for moderate carpal tunnel syndrome. International Journal of Clinical Practice, 75(10), e14482.
- Sim, S. E., Gunasagaran, J., Goh, K. J., Ahmad, T. S.. (2019). Short-term clinical outcome of orthosis alone vs combination of orthosis, nerve, and tendon gliding exercises and ultrasound therapy for treatment of carpal tunnel syndrome. Journal of Hand Therapy, 32(4), 411-416.
- Suslu, H., Turan Suslu, H., Guçlu, B., Ozdogan, S., Duzkalir, A. H., Karabagli, H.. (2016). Comparison of local steroid injection and pulsed radiofrequency neuromodulation for the treatment of mild idiopathic carpal tunnel syndrome. Journal of Neurological Sciences, 33(2), 309-314. https://www.embase.com/search/results?subaction=viewrecord&id=L610079609&from=export
- Talebi, G. A., Saadat, P., Javadian, Y., Taghipour, M.. (2018). Manual therapy in the treatment of carpal tunnel syndrome in diabetic patients: A randomized clinical trial. Caspian Journal of Internal Medicine, 9(3), 283-289.
- Toopchizadeh, V., Karimnia, S., Sadat, B. E., Jahanjoo, F., Pezeshki, M. Z.. (2020). Effects of forearm myofascial trigger point dry needling on pain and function of patients with carpal tunnel syndrome. Crescent Journal of Medical and Biological Sciences, 7(3), 362-367. https://www.embase.com/search/results?subaction=viewrecord&id=L633103030&from=export
- Vaidya, S. M., Nariya, D.. (2020). Effect of neural mobilisation versus nerve and tendon gliding exercises in carpal tunnel syndrome: A randomised clinical trial. Journal of Clinical and Diagnostic Research, 14(6), YC01-YC04. http://dx.doi.org/10.7860/JCDR/2020/43320.13779
- Wolny, T., Saulicz, E., Linek, P., Shacklock, M., Mysliwiec, A.. (2017). Efficacy of Manual Therapy Including Neurodynamic Techniques for the Treatment of Carpal Tunnel Syndrome: A Randomized Controlled Trial. Journal of Manipulative & Physiological Therapeutics, 40(4), 263-272.
- Wu, Y. T., Ho, T. Y., Chou, Y. C., Ke, M. J., Li, T. Y., Tsai, C. K., Chen, L. C.. (2017). Six-month Efficacy of Perineural Dextrose for Carpal Tunnel Syndrome: A Prospective, Randomized, Double-Blind, Controlled Trial. Mayo Clinic Proceedings, 92(8), 1179-1189.
- Wu, Y. T., Lam, K. H. S., Lai, C. Y., Chen, S. R., Shen, Y. P., Su, Y. C., Li, T. Y., Wu, C. H.. (2022). Novel Motor-Sparing Ultrasound-Guided Neural Injection in Severe Carpal Tunnel Syndrome: A Comparison of Four Injectates. BioMed Research International, 2022(0), 9745322.
- Xu, D., Ma, W., Jiang, W., Hu, X., Jiang, F., Mao, C., Wang, Y., Fang, L., Luo, N., Li, H., Lou, Z., Gan, K.. (2020). A randomized controlled trial: comparing extracorporeal shock wave therapy versus local corticosteroid injection for the treatment of carpal tunnel syndrome. International Orthopaedics, 44(1), 141-146.
- Zhang, S., Wang, F., Ke, S., Lin, C., Liu, C., Xin, W., Wu, S., Ma, C.. (2019). The Effectiveness of Ultrasound-Guided Steroid Injection Combined with Miniscalpel-Needle Release in the Treatment of Carpal Tunnel Syndrome vs. Steroid Injection Alone: A Randomized Controlled Study. BioMed Research International, 2019(0), 9498656.