CONSENSUS RECOMMENDATION Rationale
There is one low quality article that does not support the use of tranexamic acid (TXA) and multiple very low-quality articles that do support its use in reducing blood loos and/or wound complications.15
Benefits & Harms:
The risks are very low, TXA is generally considered very safe and is widely used. A benefit in wound complications, probably more so than blood loss would be very helpful in patients undergoing TAR or AA.
Outcome Importance:
Wound complications and blood loss in TAR/AA are important issues, especially wound complications.
Cost Effectiveness/Resource Utilization:
TXA is generally very cheap and used widely at most orthopaedic surgery centers and hospitals.
Acceptability:
This intervention is generally very acceptable given its wide usage in total joints, spine, and pediatric orthopaedics
Feasibility:
This intervention is generally very feasible.
Future Research:
A multi-center prospective trial would substantially strengthen the literature in this area.