LIMITED RECOMMENDATION Two moderate quality studies investigated the use of platelet rich plasma injections in mixed populations of partial and full-thickness rotator cuff tears (Akan, 2019; Centeno, 2024). This recommendation was downgraded to Limited strength for heterogeneity and inconclusive results. None of the reviewed studies provide substantial evidence for or against PRP, and its impact in the scenario of an established full-thickness rotator cuff tear.
Risks and Harms of Implementing this Recommendation
There are no known risks to PRP injections that are specific to shoulders or the rotator cuff.
Future Research
Further research may be conducted to further define the role of PRP injections in rotator cuff pathology. Future studies should standardize the technique and type of PRP formulation utilized and measure the concentrations of key components.
- Akan, O., Mete, B. D., Koçyigit, H., Bayram, K. B., Yilmaz, H. E., Tosun, A. Efficacy of ultrasound guided platelet-rich plasma in the repair of partial and full-thickness supraspinatus tears. International Journal of Clinical and Experimental Medicine 2019; 9: 11918-11929
- Centeno, C. J., Fausel, Z., Dodson, E., Berger, D. R., Steinmetz, N. J. Percutaneous bone marrow concentrate and platelet products versus exercise therapy for the treatment of rotator cuff tears: a randomized controlled, crossover trial with 2-year follow-up. BMC Musculoskeletal Disorders 2024; 1: 392