MULTIPLE STEROID INJECTIONS FOR ROTATOR CUFF TEARS
Multiple steroid injections may compromise the integrity of the rotator cuff, which may affect attempts at subsequent repair.

Rationale

Four high, four moderate and two low quality studies investigated the use of multiple steroid injections in treating rotator cuff rears (Abolhasani, 2019; Damjanov, 2018; Vaquerizo, 2023; Hsieh, 2021; Rabini, 2012; Sabaah, 2020; Hsieh, 2023, Eyigor, 2010; Sadeghifar, 2022; De Castro Correia, 2023). This recommendation was downgraded to limited strength for heterogeneity and inconclusive results. None of the reviewed studies provided evidence for or against repeated CS injections due to adverse events such as rotator cuff integrity.

Risks and Harms of Implementing this Recommendation
Corticosteroid injections in the setting of rotator cuff tears may be detrimental to the healing potential following rotator cuff repair. A single corticosteroid injection may be given to confirm the presence of rotator cuff pathology but may adversely affect outcomes if performed in temporal proximity to surgical intervention.

Future Research
Further research is recommended to determine the role of corticosteroid injections in the various settings of rotator cuff pathology.