Factors Showing No Associated Risk of CTS (Moderate Evidence)
Moderate evidence supports that the use of oral contraception and female hormone replacement therapy (HRT) are not associated with increased or decreased risk of developing carpal tunnel syndrome (CTS).
MODERATE RECOMMENDATION Rationale
Oral contraception use among females was shown to have no significant relationship to the development of CTS in three moderate quality studies (Geoghehan, 2004; Mondelli, 2006; Morgenstern, 1991). Oral HRT use among females was shown to have no significant relationship to the development of CTS in one high quality and one moderate quality study (Hakim, 2002; Geoghehan, 2004).
- Geoghegan,J.M.; Clark,D.I.; Bainbridge,L.C.; Smith,C.; Hubbard,R. Risk factors in carpal tunnel syndrome. J Hand Surg Br; 2004/8: 4
- Hakim,A.J.; Cherkas,L.; El,Zayat S.; MacGregor,A.J.; Spector,T.D. The genetic contribution to carpal tunnel syndrome in women: a twin study. Arthritis Rheum.; 2002/6/15: 3
- Mondelli,M.; Grippo,A.; Mariani,M.; Baldasseroni,A.; Ansuini,R.; Ballerini,M.; Bandinelli,C.; Graziani,M.; Luongo,F.; Mancini,R.; Manescalchi,P.; Pellegrini,S.; Sgarrella,C.; Giannini,F. Carpal tunnel syndrome and ulnar neuropathy at the elbow in floor cleaners. Neurophysiol.Clin; 2006/7: 4
- Morgenstern,H.; Kelsh,M.; Kraus,J.; Margolis,W. A cross-sectional study of hand/wrist symptoms in female grocery checkers. Am J Ind.Med; 1991: 2