Preoperative Antibiotics
Limited evidence supports that there is no benefit for routine use of prophylactic antibiotics prior to carpal tunnel release because there is no demonstrated reduction in postoperative surgical site infection.

There were two low quality studies (Harness, Tosti) which evaluated the use of prophylactic antibiotics in carpal tunnel release. Neither study showed a statistically significant difference between the groups receiving prophylactic antibiotics and those not receiving antibiotics. There is insufficient evidence to support the routine use of prophylactic antibiotics to prevent surgical site infections in carpal tunnel release.