Several high quality studies (Dammers 2006[1-3], Wong 2001, and Wong 2005) compare various doses of injected or routes of administration of methylprednisolone to treat carpal tunnel syndrome. In a double blinded, randomized study, Dammers 2006 compare the efficacy of 20, 40, and 60mg methylprednisolone injections to treat carpal tunnel syndrome. There was no significant difference in treatment response at 1 year. In a randomized double blind controlled trial, Wong 2005 compare a the effects of a single 80mg methylprednisolone injection with saline injection at 8 weeks versus two 80mg methylprednisolone injections 8 weeks apart. There was no significant difference between groups respect to Global Symptom Score, electrophysiological study, or functional outcomes (p=0.26). In a prospective randomized double-blind study, Wong 2001 compared 25mg methylprednisolone orally for 10 days and placebo injection to 15mg methylprednisolone injection with oral placebo. The steroid injection provided significant improvement based on Global Symptom Score at 12 weeks.
- Atroshi,I.; Flondell,M.; Hofer,M.; Ranstam,J. Methylprednisolone injections for the carpal tunnel syndrome: a randomized, placebo-controlled trial. Ann.Intern.Med; 2013/9/3: 5
- Dammers,J.W.; Roos,Y.; Veering,M.M.; Vermeulen,M. Injection with methylprednisolone in patients with the carpal tunnel syndrome: a randomised double blind trial testing three different doses. J Neurol; 2006/5: 5
- Wong,S.M.; Hui,A.C.; Lo,S.K.; Chiu,J.H.; Poon,W.F.; Wong,L. Single vs. two steroid injections for carpal tunnel syndrome: a randomised clinical trial. Int.J Clin Pract.; 2005/12: 12
- Wong,S.M.; Hui,A.C.; Tang,A.; Ho,P.C.; Hung,L.K.; Wong,K.S.; Kay,R.; Li,E. Local vs systemic corticosteroids in the treatment of carpal tunnel syndrome. ; 2001/6/12: 11