Cirrhosis/Hepatitis C as a Risk Factor
Limited evidence supports that patients with cirrhosis or hepatitis C are at higher risk for complications with total knee arthroplasty (TKA).
Surgical Management of Osteoarthritis of the Knee
Endorsed by: The Knee Society, SOMOS, AAHKS, ACR, AGS, AANA

Rationale
Given that the liver is the target organ for hepatitis C, these two risk factors were grouped together. Shih (2004) demonstrated higher complication rates after total knee arthroplasty in patients with cirrhosis and was assigned moderate quality. Pour (2011) was lower quality paper that demonstrated the same in patients with hepatitis C virus status alone and without liver damage. Given the one moderate study and one low quality study, the recommendation was made that limited evidence supports that patients with cirrhosis or hepatitis C are at higher risk for complications with total knee arthroplasty.
 

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