Weight Loss
We suggest weight loss for patients with symptomatic osteoarthritis of the knee and a BMI ≥ 25.

Rationale
There was one moderate- and two low- strength studies included in this recommendation. Physical Function on the SF-36 showed minimum clinically important improvement in outcomes for this patient population. WOMAC function also showed statistical improvement which was possibly clinically significant. Diet and exercise combined revealed improved results. The workgroup considers that the public and patient health benefits of weight loss warranted an upgrade of the recommendation strength to moderate. 53-55

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