Moderate strength evidence does not support the use of glucosamine sulfate because it did not perform better than placebo for improving function, reducing stiffness and decreasing pain for patients with symptomatic osteoarthritis of the hip.

A literature search for studies investigating the treatment of symptomatic hip OA with glucosamine, chondroitin, and other nutraceuticals yielded 85 studies. Only one high quality study met our inclusion criteria (Rozendaal et al). In this placebo randomized control trial study, 222 patients were given oral glucosamine or placebo and evaluated for 2 years. Glucosamine sulfate did not perform better than placebo for improving function, or reducing stiffness and pain.
  1. Maheu,E.; Cadet,C.; Marty,M.; Moyse,D.; Kerloch,I.; Coste,P.; Dougados,M.; Mazieres,B.; Spector,T.D.; Halhol,H.; Grouin,J.M.; Lequesne,M. Randomised, controlled trial of avocado-soybean unsaponifiable (Piascledine) effect on structure modification in hip osteoarthritis: the ERADIAS study. Ann Rheum.Dis; 2014/2: 2
  2. Maheu,E.; Mazieres,B.; Valat,J.P.; Loyau,G.; Le,Loet,X, Bourgeois,P.; Grouin,J.M.; Rozenberg,S. Symptomatic efficacy of avocado/soybean unsaponifiables in the treatment of osteoarthritis of the knee and hip: a prospective, randomized, double-blind, placebo-controlled, multicenter clinical trial with a six-month treatment period and a two-month followup demonstrating a persistent effect. Arthritis Rheum.; 1998/1: 1
  3. Rozendaal,R.M.; Koes,B.W.; van Osch,G.J.; Uitterlinden,E.J.; Garling,E.H.; Willemsen,S.P.; Ginai,A.Z.; Verhaar,J.A.; Weinans,H.; Bierma-Zeinstra,S.M. Effect of glucosamine sulfate on hip osteoarthritis: a randomized trial. Ann Intern.Med; 2008/2/19: 4